Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis

Mycobacterium bovis bacille Calmette-Guerin (BCG) provides only limited protection against pulmonary tuberculosis. We tested the hypothesis that BCG might have retained immunomodulatory properties from its pathogenic parent that limit its protective immunogenicity. Mutation of the molecules involved...

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Detalles Bibliográficos
Autores principales: Festjens, Nele, Bogaert, Pieter, Batni, Anjana, Houthuys, Erica, Plets, Evelyn, Vanderschaeghe, Dieter, Laukens, Bram, Asselbergh, Bob, Parthoens, Eef, De Rycke, Riet, Willart, Monique A, Jacques, Peggy, Elewaut, Dirk, Brouckaert, Peter, Lambrecht, Bart N, Huygen, Kris, Callewaert, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377067/
https://www.ncbi.nlm.nih.gov/pubmed/21328541
http://dx.doi.org/10.1002/emmm.201000125

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