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Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis
The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these proteins has focused on mammalian Target of Rapamycin (mTOR), a target of Rheb. H...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377068/ https://www.ncbi.nlm.nih.gov/pubmed/21412983 http://dx.doi.org/10.1002/emmm.201100131 |
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author | Neuman, Nicole A Henske, Elizabeth Petri |
author_facet | Neuman, Nicole A Henske, Elizabeth Petri |
author_sort | Neuman, Nicole A |
collection | PubMed |
description | The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these proteins has focused on mammalian Target of Rapamycin (mTOR), a target of Rheb. Here, we propose that there are clinically relevant functions and targets of TSC1, TSC2 and Rheb, which are independent of mTOR. We present evidence that such non-canonical functions of the TSC-Rheb signalling network exist, propose a standard of evidence for these non-canonical functions, and discuss their potential clinical and therapeutic implications for patients with TSC and lymphangioleiomyomatosis (LAM). |
format | Online Article Text |
id | pubmed-3377068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | WILEY-VCH Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33770682012-09-17 Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis Neuman, Nicole A Henske, Elizabeth Petri EMBO Mol Med In Focus The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these proteins has focused on mammalian Target of Rapamycin (mTOR), a target of Rheb. Here, we propose that there are clinically relevant functions and targets of TSC1, TSC2 and Rheb, which are independent of mTOR. We present evidence that such non-canonical functions of the TSC-Rheb signalling network exist, propose a standard of evidence for these non-canonical functions, and discuss their potential clinical and therapeutic implications for patients with TSC and lymphangioleiomyomatosis (LAM). WILEY-VCH Verlag 2011-04 /pmc/articles/PMC3377068/ /pubmed/21412983 http://dx.doi.org/10.1002/emmm.201100131 Text en Copyright © 2011 EMBO Molecular Medicine |
spellingShingle | In Focus Neuman, Nicole A Henske, Elizabeth Petri Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis |
title | Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis |
title_full | Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis |
title_fullStr | Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis |
title_full_unstemmed | Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis |
title_short | Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis |
title_sort | non-canonical functions of the tuberous sclerosis complex-rheb signalling axis |
topic | In Focus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377068/ https://www.ncbi.nlm.nih.gov/pubmed/21412983 http://dx.doi.org/10.1002/emmm.201100131 |
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