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Systemic low-molecular weight drug delivery to pre-selected neuronal regions

We describe a procedure for controlled, periodic, reversible modulation of selected regions of the blood–brain barrier (BBB) or the inner-blood–retina barrier (iBRB) based on incorporation into an AAV-2/9 vector of a doxycycline-inducible gene encoding shRNA targeting claudin-5, one of 30 or so prot...

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Detalles Bibliográficos
Autores principales:	Campbell, Matthew, Humphries, Marian M, Kiang, Anna-Sophia, Nguyen, Anh T H, Gobbo, Oliviero L, Tam, Lawrence C S, Suzuki, Mayu, Hanrahan, Finnian, Ozaki, Ema, Farrar, G-Jane, Kenna, Paul F, Humphries, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377070/ https://www.ncbi.nlm.nih.gov/pubmed/21374818 http://dx.doi.org/10.1002/emmm.201100126

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