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Divide and conquer: the genetic basis of molecular subclassification of breast cancer
Since the luminal B tumours are associated with poor recurrence-free and disease-specific survivals in all adjuvant systemic treatment categories including hormone therapy, the identification of specific signalling pathways driving luminal B biology is paramount to improve treatment. Sircoulomb et a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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WILEY-VCH Verlag
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377072/ https://www.ncbi.nlm.nih.gov/pubmed/21394915 http://dx.doi.org/10.1002/emmm.201100128 |
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author | Kristensen, Vessela N |
author_facet | Kristensen, Vessela N |
author_sort | Kristensen, Vessela N |
collection | PubMed |
description | Since the luminal B tumours are associated with poor recurrence-free and disease-specific survivals in all adjuvant systemic treatment categories including hormone therapy, the identification of specific signalling pathways driving luminal B biology is paramount to improve treatment. Sircoulomb et al. and Holland et al. have independently identified the ZNF703 gene, located in chromosomal region 8p12, as preferentially amplified in luminal B tumours. |
format | Online Article Text |
id | pubmed-3377072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | WILEY-VCH Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33770722012-09-17 Divide and conquer: the genetic basis of molecular subclassification of breast cancer Kristensen, Vessela N EMBO Mol Med Closeup Since the luminal B tumours are associated with poor recurrence-free and disease-specific survivals in all adjuvant systemic treatment categories including hormone therapy, the identification of specific signalling pathways driving luminal B biology is paramount to improve treatment. Sircoulomb et al. and Holland et al. have independently identified the ZNF703 gene, located in chromosomal region 8p12, as preferentially amplified in luminal B tumours. WILEY-VCH Verlag 2011-04 /pmc/articles/PMC3377072/ /pubmed/21394915 http://dx.doi.org/10.1002/emmm.201100128 Text en Copyright © 2011 EMBO Molecular Medicine |
spellingShingle | Closeup Kristensen, Vessela N Divide and conquer: the genetic basis of molecular subclassification of breast cancer |
title | Divide and conquer: the genetic basis of molecular subclassification of breast cancer |
title_full | Divide and conquer: the genetic basis of molecular subclassification of breast cancer |
title_fullStr | Divide and conquer: the genetic basis of molecular subclassification of breast cancer |
title_full_unstemmed | Divide and conquer: the genetic basis of molecular subclassification of breast cancer |
title_short | Divide and conquer: the genetic basis of molecular subclassification of breast cancer |
title_sort | divide and conquer: the genetic basis of molecular subclassification of breast cancer |
topic | Closeup |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377072/ https://www.ncbi.nlm.nih.gov/pubmed/21394915 http://dx.doi.org/10.1002/emmm.201100128 |
work_keys_str_mv | AT kristensenvesselan divideandconquerthegeneticbasisofmolecularsubclassificationofbreastcancer |