Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

Lafora disease (LD) is caused by mutations in either the laforin or malin gene. The hallmark of the disease is the accumulation of polyglucosan inclusions called Lafora Bodies (LBs). Malin knockout (KO) mice present polyglucosan accumulations in several brain areas, as do patients of LD. These struc...

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Detalles Bibliográficos
Autores principales: Valles-Ortega, Jordi, Duran, Jordi, Garcia-Rocha, Mar, Bosch, Carles, Saez, Isabel, Pujadas, Lluís, Serafin, Anna, Cañas, Xavier, Soriano, Eduardo, Delgado-García, José M, Gruart, Agnès, Guinovart, Joan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377110/
https://www.ncbi.nlm.nih.gov/pubmed/21882344
http://dx.doi.org/10.1002/emmm.201100174

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