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Role of the WNK-activated SPAK kinase in regulating blood pressure
Mutations within the with-no-K(Lys) (WNK) kinases cause Gordon's syndrome characterized by hypertension and hyperkalaemia. WNK kinases phosphorylate and activate the STE20/SPS1-related proline/alanine-rich kinase (SPAK) protein kinase, which phosphorylates and stimulates the key Na(+):Cl(−) cot...
Autores principales: | Rafiqi, Fatema H, Zuber, Annie Mercier, Glover, Mark, Richardson, Ciaran, Fleming, Stewart, Jovanović, Sofija, Jovanović, Aleksandar, O'Shaughnessy, Kevin M, Alessi, Dario R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377268/ https://www.ncbi.nlm.nih.gov/pubmed/20091762 http://dx.doi.org/10.1002/emmm.200900058 |
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