Cargando…

Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

The role for cellular prion protein PrP(c) in β-amyloid (Aβ) oligomer-induced synaptic impairment is a topic of great interest and some controversy. In this issue of EMBO Molecular Medicine Aguzzi and co-workers explore the contribution of PrP(c) to deficient long term potentiation (LTP) and soluble...

Descripción completa

Detalles Bibliográficos
Autores principales: Benilova, Iryna, De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377329/
https://www.ncbi.nlm.nih.gov/pubmed/20698011
http://dx.doi.org/10.1002/emmm.201000088
Descripción
Sumario:The role for cellular prion protein PrP(c) in β-amyloid (Aβ) oligomer-induced synaptic impairment is a topic of great interest and some controversy. In this issue of EMBO Molecular Medicine Aguzzi and co-workers explore the contribution of PrP(c) to deficient long term potentiation (LTP) and soluble Aβ levels in an Alzheimer's disease mouse model and show that the role of prions in Aβ related toxicity is far from ‘black and white’ suggesting complex interpretations of the data available thus far.