Cargando…

αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson's Disease?

Parkinson's Disease (PD) is a complex, chronic, progressive, and debilitating neurodegenerative disorder. Neither a cure nor effective long-term therapy exist and the lack of knowledge of the molecular mechanisms responsible for PD development is a major impediment to therapeutic advances. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Protter, David, Lang, Charmaine, Cooper, Antony A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377350/ https://www.ncbi.nlm.nih.gov/pubmed/22737587 http://dx.doi.org/10.1155/2012/829207

Ejemplares similares

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
por: Zaltieri, Michela, et al.
Publicado: (2015)

Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
por: Risiglione, Pierpaolo, et al.
Publicado: (2021)

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
por: Bender, Andreas, et al.
Publicado: (2013)

Potential for Therapeutic-Loaded Exosomes to Ameliorate the Pathogenic Effects of α-Synuclein in Parkinson’s Disease
por: Rademacher, David J.
Publicado: (2023)

Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?
por: Pozo Devoto, Victorio M., et al.
Publicado: (2017)

LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease
por: Esteves, A. Raquel, et al.
Publicado: (2023)

Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation
por: Wang, Changjing, et al.
Publicado: (2021)

Immunological features of α-synuclein in Parkinson's disease
por: Roodveldt, Cintia, et al.
Publicado: (2008)

Models of α-synuclein aggregation in Parkinson’s disease
por: Giráldez-Pérez, Rosa María, et al.
Publicado: (2014)

The Role of α-Synuclein Oligomers in Parkinson’s Disease
por: Du, Xiao-yu, et al.
Publicado: (2020)

Linking α-synuclein-induced synaptopathy and neural network dysfunction in early Parkinson’s disease
por: Kulkarni, Aishwarya S, et al.
Publicado: (2022)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
por: Zambon, Federico, et al.
Publicado: (2019)

α - synuclein and Parkinson’s disease: the first roadblock
por: Lin Chua, Christelle En, et al.
Publicado: (2006)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
por: Tofaris, George K.
Publicado: (2022)

The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy
por: Longhena, Francesca, et al.
Publicado: (2017)

Characterization of the pathogenic α-Synuclein Variant V15A in Parkinson´s disease
por: Diaw, Sokhna Haissatou, et al.
Publicado: (2023)

α-Synuclein inclusions in the skin of Parkinson's disease and parkinsonism
por: Rodríguez-Leyva, Ildefonso, et al.
Publicado: (2014)

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
por: Faustini, Gaia, et al.
Publicado: (2017)

Association of Glial Activation and α-Synuclein Pathology in Parkinson’s Disease
por: Wang, Rui, et al.
Publicado: (2022)

PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s Disease
por: Li, Wen, et al.
Publicado: (2021)

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease
por: Liu, Wencheng, et al.
Publicado: (2009)

Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease
por: Phan, Jenny-Ann, et al.
Publicado: (2017)

Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
por: Recasens, Ariadna, et al.
Publicado: (2018)

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
por: Winslow, Ashley R., et al.
Publicado: (2010)

Mitochondrial dysfunction in Parkinson’s disease
por: Hu, Qingsong, et al.
Publicado: (2016)

Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease
por: Emamzadeh, Fatemeh Nouri
Publicado: (2017)

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease
por: Du, Tingting, et al.
Publicado: (2021)

α-Synuclein and Anti-α-Synuclein Antibodies in Parkinson’s Disease, Atypical Parkinson Syndromes, REM Sleep Behavior Disorder, and Healthy Controls
por: Smith, Lynnae M., et al.
Publicado: (2012)

The Nigral Coup in Parkinson’s Disease by α-Synuclein and Its Associated Rebels
por: Sian-Hulsmann, Jeswinder, et al.
Publicado: (2021)

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies
por: Kawahata, Ichiro, et al.
Publicado: (2022)

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease
por: Suzuki, Mari, et al.
Publicado: (2022)

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
por: Kang, Wenyan, et al.
Publicado: (2016)

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
por: Schulz-Schaeffer, Walter J.
Publicado: (2010)

Mitochondrial Dysfunction in Parkinson's Disease
por: Keane, P. C., et al.
Publicado: (2011)

Mitochondrial Dysfunction in Parkinson's Disease
por: Moon, Hyo Eun, et al.
Publicado: (2015)

Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling
por: Hong, Chien-Tai, et al.
Publicado: (2020)

Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease
por: Castillo-Gonzalez, Juan Antonio, et al.
Publicado: (2017)

MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson's Disease
por: Zhao, Liang, et al.
Publicado: (2019)

Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson's Disease
por: Wei, Jianshe, et al.
Publicado: (2021)

Relation of Enteric α-Synuclein to Gastrointestinal Dysfunction in Patients With Parkinson’s Disease and in Neurologically Intact Subjects
por: Lee, Hyo Jeong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0ng24o3te8vq7vgg8r5asm3d8n