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Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006

We analyzed data from hospital admissions and enhanced mumps surveillance to assess mumps complications during the largest mumps outbreak in England and Wales, 2004–2005, and their association with mumps vaccination. When compared with nonoutbreak periods, the outbreak was associated with a clear in...

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Autores principales: Yung, Chee-Fu, Andrews, Nick, Bukasa, Antoaneta, Brown, Kevin E., Ramsay, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377415/
https://www.ncbi.nlm.nih.gov/pubmed/21470456
http://dx.doi.org/10.3201/eid1704.101461
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author Yung, Chee-Fu
Andrews, Nick
Bukasa, Antoaneta
Brown, Kevin E.
Ramsay, Mary
author_facet Yung, Chee-Fu
Andrews, Nick
Bukasa, Antoaneta
Brown, Kevin E.
Ramsay, Mary
author_sort Yung, Chee-Fu
collection PubMed
description We analyzed data from hospital admissions and enhanced mumps surveillance to assess mumps complications during the largest mumps outbreak in England and Wales, 2004–2005, and their association with mumps vaccination. When compared with nonoutbreak periods, the outbreak was associated with a clear increase in hospitalized patients with orchitis, meningitis, and pancreatitis. Routine mumps surveillance and hospital data showed that 6.1% of estimated mumps patients were hospitalized, 4.4% had orchitis, 0.35% meningitis, and 0.33% pancreatitis. Enhanced surveillance data showed 2.9% of mumps patients were hospitalized, 6.1% had orchitis, 0.3% had meningitis, and 0.25% had pancreatitis. Risk was reduced for hospitalization (odds ratio [OR] 0.54, 95% confidence interval [CI] 0.43–0.68), mumps orchitis (OR 0.72, 95% CI 0.56–0.93) and mumps meningitis (OR 0.28, 95% CI 0.14–0.56) when patient had received 1 dose of measles, mumps, and rubella vaccine. The protective effect of vaccination on disease severity is critical in assessing the total effects of current and future mumps control strategies.
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spelling pubmed-33774152012-06-20 Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006 Yung, Chee-Fu Andrews, Nick Bukasa, Antoaneta Brown, Kevin E. Ramsay, Mary Emerg Infect Dis Research We analyzed data from hospital admissions and enhanced mumps surveillance to assess mumps complications during the largest mumps outbreak in England and Wales, 2004–2005, and their association with mumps vaccination. When compared with nonoutbreak periods, the outbreak was associated with a clear increase in hospitalized patients with orchitis, meningitis, and pancreatitis. Routine mumps surveillance and hospital data showed that 6.1% of estimated mumps patients were hospitalized, 4.4% had orchitis, 0.35% meningitis, and 0.33% pancreatitis. Enhanced surveillance data showed 2.9% of mumps patients were hospitalized, 6.1% had orchitis, 0.3% had meningitis, and 0.25% had pancreatitis. Risk was reduced for hospitalization (odds ratio [OR] 0.54, 95% confidence interval [CI] 0.43–0.68), mumps orchitis (OR 0.72, 95% CI 0.56–0.93) and mumps meningitis (OR 0.28, 95% CI 0.14–0.56) when patient had received 1 dose of measles, mumps, and rubella vaccine. The protective effect of vaccination on disease severity is critical in assessing the total effects of current and future mumps control strategies. Centers for Disease Control and Prevention 2011-04 /pmc/articles/PMC3377415/ /pubmed/21470456 http://dx.doi.org/10.3201/eid1704.101461 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Yung, Chee-Fu
Andrews, Nick
Bukasa, Antoaneta
Brown, Kevin E.
Ramsay, Mary
Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006
title Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006
title_full Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006
title_fullStr Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006
title_full_unstemmed Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006
title_short Mumps Complications and Effects of Mumps Vaccination, England and Wales, 2002–2006
title_sort mumps complications and effects of mumps vaccination, england and wales, 2002–2006
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377415/
https://www.ncbi.nlm.nih.gov/pubmed/21470456
http://dx.doi.org/10.3201/eid1704.101461
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