TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo

Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family and is involved in cytokine signalling. In vitro analyses suggest that TYK2 also has kinase-independent, i.e., non-canonical, functions. We have generated gene-targeted mice harbouring a mutation in the ATP-binding pocket of the k...

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Detalles Bibliográficos
Autores principales: Prchal-Murphy, Michaela, Semper, Christian, Lassnig, Caroline, Wallner, Barbara, Gausterer, Christian, Teppner-Klymiuk, Ingeborg, Kobolak, Julianna, Müller, Simone, Kolbe, Thomas, Karaghiosoff, Marina, Dinnyés, Andras, Rülicke, Thomas, Leitner, Nicole R., Strobl, Birgit, Müller, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377589/
https://www.ncbi.nlm.nih.gov/pubmed/22723949
http://dx.doi.org/10.1371/journal.pone.0039141

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