Cargando…

Analysis of her1 and her7 Mutants Reveals a Spatio Temporal Separation of the Somite Clock Module

Somitogenesis is controlled by a genetic network consisting of an oscillator (clock) and a gradient (wavefront). The “hairy and Enhancer of Split”- related (her) genes act downstream of the Delta/Notch (D/N) signaling pathway, and are crucial components of the segmentation clock. Due to genome dupli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choorapoikayil, Suma, Willems, Bernd, Ströhle, Peter, Gajewski, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377618/ https://www.ncbi.nlm.nih.gov/pubmed/22723933 http://dx.doi.org/10.1371/journal.pone.0039073

Ejemplares similares

Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling
por: Jenkins, Robert P., et al.
Publicado: (2015)

Cell–Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis
por: Gomes de Almeida, Patrícia, et al.
Publicado: (2022)

The period of the somite segmentation clock is sensitive to Notch activity
por: Kim, Woong, et al.
Publicado: (2011)

Notch signaling, the segmentation clock, and the patterning of vertebrate somites
por: Lewis, Julian, et al.
Publicado: (2009)

Setting the Tempo in Development: An Investigation of the Zebrafish Somite Clock Mechanism
por: Giudicelli, François, et al.
Publicado: (2007)

Mutant HER2 needs mutant HER3 to be an effective oncogene
por: Trenker, Raphael, et al.
Publicado: (2021)

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function
por: Anderson, Matthew J, et al.
Publicado: (2020)

HER kinase inhibition in patients with HER2- and HER3-mutant cancers
por: Hyman, David M., et al.
Publicado: (2018)

Notch Signalling Synchronizes the Zebrafish Segmentation Clock but Is Not Needed To Create Somite Boundaries
por: Özbudak, Ertuğrul M, et al.
Publicado: (2008)

Development of somites and their derivatives in amphioxus, and implications for the evolution of vertebrate somites
por: Mansfield, Jennifer H, et al.
Publicado: (2015)

On the origin of vertebrate somites
por: Onai, Takayuki, et al.
Publicado: (2015)

Hes7 3′UTR is required for somite segmentation function
por: Fujimuro, Takeshi, et al.
Publicado: (2014)

CT features of HER2-mutant lung adenocarcinomas
por: Sawan, Peter, et al.
Publicado: (2018)

Tbx Protein Level Critical for Clock-Mediated Somite Positioning Is Regulated through Interaction between Tbx and Ripply
por: Wanglar, Chimwar, et al.
Publicado: (2014)

Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor
por: Hu, Zexi, et al.
Publicado: (2015)

Clinical outcomes of patients with HER2-mutant advanced lung cancer: chemotherapies versus HER2-directed therapies
por: Zhou, Jiebai, et al.
Publicado: (2020)

SOMITE CHONDROGENESIS : A Structural Analysis
por: Minor, Ronald R.
Publicado: (1973)

Constraints on somite formation in developing embryos
por: Juul, Jonas S., et al.
Publicado: (2019)

Molecular and Mechanical Cues for Somite Periodicity
por: Linde-Medina, Marta, et al.
Publicado: (2021)

The uncharted role of HER2 mutant alleles in breast cancer
por: Kalra, Rashi, et al.
Publicado: (2023)

Taming of Modulation Instability by Spatio-Temporal Modulation of the Potential
por: Kumar, S., et al.
Publicado: (2015)

Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
por: Sassen, Andrea, et al.
Publicado: (2008)

Correction: Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor
por: Hu, Zexi, et al.
Publicado: (2018)

Genomic landscape and efficacy of HER2-targeted therapy in patients with HER2-mutant non-small cell lung cancer
por: Han, Yanjie, et al.
Publicado: (2023)

NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies
por: Khalil, Hilal S., et al.
Publicado: (2016)

Outcomes of Pemetrexed-based chemotherapies in HER2-mutant lung cancers
por: Wang, Yan, et al.
Publicado: (2018)

Structural investigations on mechanism of lapatinib resistance caused by HER-2 mutants
por: Verma, Sharad, et al.
Publicado: (2018)

Mechanisms of neratinib resistance in HER2-mutant metastatic breast cancer
por: Eli, Lisa D., et al.
Publicado: (2022)

The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers
por: Majumder, Avisek, et al.
Publicado: (2021)

A mechanical model of early somite segmentation
por: Adhyapok, Priyom, et al.
Publicado: (2021)

A Spatio-Temporal Model of Notch Signalling in the Zebrafish Segmentation Clock: Conditions for Synchronised Oscillatory Dynamics
por: Terry, Alan J., et al.
Publicado: (2011)

Model-Based Analysis of HER Activation in Cells Co-Expressing EGFR, HER2 and HER3
por: Shankaran, Harish, et al.
Publicado: (2013)

H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation via heregulin production and activation of HER3
por: Chakrabarty, Anindita, et al.
Publicado: (2010)

The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients
por: Memon, A A, et al.
Publicado: (2006)

“Everything for Her!”
por: Andrijević Matovac, Vesna
Publicado: (2011)

In her family /
por: Metheny, Pat
Publicado: (1987)

ADVICE TO THE EXPECTANT MOTHER ON THE CARE OF HER HEALTH AND THAT OF HER CHILD
Publicado: (1947)

HER-3 expression in HER-2-amplified breast carcinoma
por: Czopek, Jacek, et al.
Publicado: (2013)

Advice to the Expectant Mother on the Care of Her Health and That of Her Child
Publicado: (1947)

Advice to the Expectant Mother on the Care of Her Health and That of Her Child
Publicado: (1943)

Cannot write session to /tmp/vufind_sessions/sess_hut36hu1f890vsmrc9kg9l4qpg