Attenuation of Soft-Tissue Sarcomas Resistance to the Cytotoxic Action of TNF-α by Restoring p53 Function

BACKGROUND: Isolated limb perfusion with TNF-α and melphalan is used with remarkable efficiency to treat unresectable limb sarcomas. Here we tested the ability of TNF-α to directly induce apoptosis of sarcoma cells. In addition, we investigated the impact of p53 in the regulation of such effect. MET...

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Detalles Bibliográficos
Autores principales: Muret, Jane, Hasmim, Meriem, Stasik, Izabela, Jalil, Abdelali, Mallavialle, Aude, Nanbakhsh, Arash, Lacroix, Ludovic, Billot, Katy, Baud, Véronique, Thiery, Jérome, Vielh, Philippe, Terrier, Philippe, Wiels, Joelle, Vassilev, Lyubomir, Lecesne, Axel, Bonvalot, Sylvie, Chouaib, Salem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377724/
https://www.ncbi.nlm.nih.gov/pubmed/22719951
http://dx.doi.org/10.1371/journal.pone.0038808

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