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Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
It has been postulated that mucus stasis is central to the pathogenesis of obstructive lung diseases. In Scnn1b-transgenic (Scnn1b-Tg(+)) mice, airway-targeted overexpression of the epithelial Na(+) channel β subunit causes airway surface dehydration, which results in mucus stasis and inflammation....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377774/ https://www.ncbi.nlm.nih.gov/pubmed/22419116 http://dx.doi.org/10.1038/mi.2012.17 |