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Role of female sex hormones, estradiol and progesterone, in mast cell behavior

Female sex hormones have long been suspected to have an effect on mast cell (MC) behavior. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different prevalence in females than in males. Further,...

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Detalles Bibliográficos
Autores principales: Zierau, Oliver, Zenclussen, Ana C., Jensen, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377947/
https://www.ncbi.nlm.nih.gov/pubmed/22723800
http://dx.doi.org/10.3389/fimmu.2012.00169
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author Zierau, Oliver
Zenclussen, Ana C.
Jensen, Federico
author_facet Zierau, Oliver
Zenclussen, Ana C.
Jensen, Federico
author_sort Zierau, Oliver
collection PubMed
description Female sex hormones have long been suspected to have an effect on mast cell (MC) behavior. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different prevalence in females than in males. Further, serum IgE levels are much higher in allergic female mice compared to male mice. Ovariectomized rats developed less airway inflammation compared to sham controls. Following estrogen replacement ovariectomized rats re-established airway inflammation levels’ found in intact females. In humans, a much higher asthma prevalence was found in women at reproductive age as compared to men. Serum levels of estradiol and progesterone have been directly correlated with the clinical and functional features of asthma. Around 30–40% of women who have asthma experienced worsening of their symptoms during the perimenstrual phase, the so-called perimenstrual asthma. Postmenopausal women receiving hormone replacement therapy have an increased risk of new onset of asthma. Beside, estrus cycle dependent changes on female sex hormones are related to changes on MC number in mouse uterine tissue and estradiol and progesterone were shown to induce uterine MC maturation and degranulation. We will discuss here the currently available information concerning the role of these female sex hormones on MC behavior.
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spelling pubmed-33779472012-06-21 Role of female sex hormones, estradiol and progesterone, in mast cell behavior Zierau, Oliver Zenclussen, Ana C. Jensen, Federico Front Immunol Immunology Female sex hormones have long been suspected to have an effect on mast cell (MC) behavior. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different prevalence in females than in males. Further, serum IgE levels are much higher in allergic female mice compared to male mice. Ovariectomized rats developed less airway inflammation compared to sham controls. Following estrogen replacement ovariectomized rats re-established airway inflammation levels’ found in intact females. In humans, a much higher asthma prevalence was found in women at reproductive age as compared to men. Serum levels of estradiol and progesterone have been directly correlated with the clinical and functional features of asthma. Around 30–40% of women who have asthma experienced worsening of their symptoms during the perimenstrual phase, the so-called perimenstrual asthma. Postmenopausal women receiving hormone replacement therapy have an increased risk of new onset of asthma. Beside, estrus cycle dependent changes on female sex hormones are related to changes on MC number in mouse uterine tissue and estradiol and progesterone were shown to induce uterine MC maturation and degranulation. We will discuss here the currently available information concerning the role of these female sex hormones on MC behavior. Frontiers Research Foundation 2012-06-19 /pmc/articles/PMC3377947/ /pubmed/22723800 http://dx.doi.org/10.3389/fimmu.2012.00169 Text en Copyright © Zierau, Zenclussen and Jensen. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) , which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
Zierau, Oliver
Zenclussen, Ana C.
Jensen, Federico
Role of female sex hormones, estradiol and progesterone, in mast cell behavior
title Role of female sex hormones, estradiol and progesterone, in mast cell behavior
title_full Role of female sex hormones, estradiol and progesterone, in mast cell behavior
title_fullStr Role of female sex hormones, estradiol and progesterone, in mast cell behavior
title_full_unstemmed Role of female sex hormones, estradiol and progesterone, in mast cell behavior
title_short Role of female sex hormones, estradiol and progesterone, in mast cell behavior
title_sort role of female sex hormones, estradiol and progesterone, in mast cell behavior
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377947/
https://www.ncbi.nlm.nih.gov/pubmed/22723800
http://dx.doi.org/10.3389/fimmu.2012.00169
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