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How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

T cell signaling begins with the ligation of the T cell antigen receptor (TCR) by a cognate peptide and the phosphorylation of the receptor’s immunoreceptor tyrosine-based activation motif domains by the kinase Lck. However, the canonical receptor model is insufficient to explain how the constitutiv...

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Detalles Bibliográficos
Autores principales:	Rossy, Jérémie, Williamson, David J., Gaus, Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377954/ https://www.ncbi.nlm.nih.gov/pubmed/22723799 http://dx.doi.org/10.3389/fimmu.2012.00167

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