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Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status

Long-term exposure to ascorbate is known to enhance endothelial nitric oxide synthase (eNOS) activity by stabilizing the eNOS cofactor tetrahydrobiopterin (BH4). We investigated acute effects of ascorbate on eNOS function in primary (HUVEC) and immortalized human endothelial cells (EA.hy926), aiming...

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Detalles Bibliográficos
Autores principales:	Ladurner, Angela, Schmitt, Christoph A., Schachner, Daniel, Atanasov, Atanas G., Werner, Ernst R., Dirsch, Verena M., Heiss, Elke H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2012
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377995/ https://www.ncbi.nlm.nih.gov/pubmed/22542797 http://dx.doi.org/10.1016/j.freeradbiomed.2012.03.022

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