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More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome

Psychiatric disorders are a common, severe and disabling group of diseases where progress in finding novel molecular targets has been slow. This is partly due to our lack of understanding of the molecular pathophysiology of these conditions as they play out in the brain (Insel & Scolnick, 2006)....

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Autor principal: Meyer-Lindenberg, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378111/
https://www.ncbi.nlm.nih.gov/pubmed/20049698
http://dx.doi.org/10.1002/emmm.200900007
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author Meyer-Lindenberg, Andreas
author_facet Meyer-Lindenberg, Andreas
author_sort Meyer-Lindenberg, Andreas
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description Psychiatric disorders are a common, severe and disabling group of diseases where progress in finding novel molecular targets has been slow. This is partly due to our lack of understanding of the molecular pathophysiology of these conditions as they play out in the brain (Insel & Scolnick, 2006). Since many of these diseases (such as schizophrenia, bipolar disorder or autism) are highly heritable, a genetic approach to dissecting the risk architecture is a promising avenue for molecular medicine; however, variants in single genes frequently present in the population have only small to moderate effects on complex behavioural phenotypes (O'Donovan et al, 2008).
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spelling pubmed-33781112012-09-17 More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome Meyer-Lindenberg, Andreas EMBO Mol Med Closeup Psychiatric disorders are a common, severe and disabling group of diseases where progress in finding novel molecular targets has been slow. This is partly due to our lack of understanding of the molecular pathophysiology of these conditions as they play out in the brain (Insel & Scolnick, 2006). Since many of these diseases (such as schizophrenia, bipolar disorder or autism) are highly heritable, a genetic approach to dissecting the risk architecture is a promising avenue for molecular medicine; however, variants in single genes frequently present in the population have only small to moderate effects on complex behavioural phenotypes (O'Donovan et al, 2008). WILEY-VCH Verlag 2009-04 /pmc/articles/PMC3378111/ /pubmed/20049698 http://dx.doi.org/10.1002/emmm.200900007 Text en Copyright © 2009 EMBO Molecular Medicine
spellingShingle Closeup
Meyer-Lindenberg, Andreas
More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome
title More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome
title_full More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome
title_fullStr More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome
title_full_unstemmed More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome
title_short More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams–Beuren syndrome
title_sort more than the sum of its parts: new mouse models for dissecting the genetic complexities of williams–beuren syndrome
topic Closeup
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378111/
https://www.ncbi.nlm.nih.gov/pubmed/20049698
http://dx.doi.org/10.1002/emmm.200900007
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