A surrogate marker for Aβ42 production in the CNS

Alzheimer's disease (AD) is the most common cause of dementia. There are currently no effective treatments that may delay the onset, slow the progression or prevent the disease. Unless such treatments are developed, the number of AD cases is expected to double in the next 30 years. There is ove...

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Detalles Bibliográficos
Autor principal: Holtzman, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2009
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378130/
https://www.ncbi.nlm.nih.gov/pubmed/20049720
http://dx.doi.org/10.1002/emmm.200900030
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author Holtzman, David M
author_facet Holtzman, David M
author_sort Holtzman, David M
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description Alzheimer's disease (AD) is the most common cause of dementia. There are currently no effective treatments that may delay the onset, slow the progression or prevent the disease. Unless such treatments are developed, the number of AD cases is expected to double in the next 30 years. There is overwhelming genetic and biochemical evidence that the aggregation and buildup of the amyloid-β (Aβ) peptide plays a critical role in AD pathogenesis.
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spelling pubmed-33781302012-09-17 A surrogate marker for Aβ42 production in the CNS Holtzman, David M EMBO Mol Med Closeup Alzheimer's disease (AD) is the most common cause of dementia. There are currently no effective treatments that may delay the onset, slow the progression or prevent the disease. Unless such treatments are developed, the number of AD cases is expected to double in the next 30 years. There is overwhelming genetic and biochemical evidence that the aggregation and buildup of the amyloid-β (Aβ) peptide plays a critical role in AD pathogenesis. WILEY-VCH Verlag 2009-07 /pmc/articles/PMC3378130/ /pubmed/20049720 http://dx.doi.org/10.1002/emmm.200900030 Text en Copyright © 2009 EMBO Molecular Medicine
spellingShingle Closeup
Holtzman, David M
A surrogate marker for Aβ42 production in the CNS
title A surrogate marker for Aβ42 production in the CNS
title_full A surrogate marker for Aβ42 production in the CNS
title_fullStr A surrogate marker for Aβ42 production in the CNS
title_full_unstemmed A surrogate marker for Aβ42 production in the CNS
title_short A surrogate marker for Aβ42 production in the CNS
title_sort surrogate marker for aβ42 production in the cns
topic Closeup
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378130/
https://www.ncbi.nlm.nih.gov/pubmed/20049720
http://dx.doi.org/10.1002/emmm.200900030
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