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Functional Characterization of the Plasmodium falciparum Chloroquine-Resistance Transporter (PfCRT) in Transformed Dictyostelium discoideum Vesicles

BACKGROUND: Chloroquine (CQ)-resistant Plasmodium falciparum malaria has been a global health catastrophe, yet much about the CQ resistance (CQR) mechanism remains unclear. Hallmarks of the CQR phenotype include reduced accumulation of protonated CQ as a weak base in the digestive vacuole of the ery...

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Detalles Bibliográficos
Autores principales:	Papakrivos, Janni, Sá, Juliana M., Wellems, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378554/ https://www.ncbi.nlm.nih.gov/pubmed/22724026 http://dx.doi.org/10.1371/journal.pone.0039569

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