Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration

NOTCH1 is frequently mutated in T-cell acute lymphoblastic leukaemia (T-ALL), and can stimulate T-ALL cell survival and proliferation. Here we explore the hypothesis that Notch1 also alters T-ALL cell migration. Rho GTPases are well-known to regulate cell adhesion and migration. We have analysed the...

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Detalles Bibliográficos
Autores principales: Bhavsar, Parag J., Infante, Elvira, Khwaja, Asim, Ridley, Anne J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378627/
https://www.ncbi.nlm.nih.gov/pubmed/22349824
http://dx.doi.org/10.1038/onc.2012.42

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