Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

Though genome-wide association studies (GWAS) have identified the existence of numerous population-based cancer susceptibility loci, mechanistic insights remain limited, particularly for intergenic polymorphisms. Here we show that polymorphism at a remote intergenic region on chromosome 11q13.3, rec...

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Detalles Bibliográficos
Autores principales: Schödel, Johannes, Bardella, Chiara, Sciesielski, Lina K, Brown, Jill M, Pugh, Chris W, Buckle, Veronica, Tomlinson, Ian P, Ratcliffe, Peter J, Mole, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378637/
https://www.ncbi.nlm.nih.gov/pubmed/22406644
http://dx.doi.org/10.1038/ng.2204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378637/
https://www.ncbi.nlm.nih.gov/pubmed/22406644
http://dx.doi.org/10.1038/ng.2204

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