Cargando…

5T4 oncofoetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype

Although the overall prognosis in childhood acute lymphoblastic leukaemia (ALL) is good, outcome after relapse is poor. Recurrence is frequently characterised by the occurrence of disease at extramedullary sites such as the central nervous system and testes. Subpopulations of blasts able to migrate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castro, Fernanda V, McGinn, Owen J, Krishnan, Shekhar, Marinov, Georgi, Li, Jian, Rutkowski, Andrzej J, Elkord, Eyad, Burt, Debbie, Holland, Mark, Vaghjiani, Rasilaben, Gallego, Aurelia, Saha, Vaskar, Stern, Peter L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378689/ https://www.ncbi.nlm.nih.gov/pubmed/22266911 http://dx.doi.org/10.1038/leu.2012.18

Ejemplares similares

Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia
por: McGinn, Owen J., et al.
Publicado: (2017)

Oncofoetal antigens in cancer of the cervix and ovary.
por: Cauchi, M. N., et al.
Publicado: (1981)

Another oncofoetal antigen in colonic carcinoma.
por: Ma, J., et al.
Publicado: (1980)

Oncofoetal antigen I: a target for immune cytolysis of human cancer.
por: Sidell, N., et al.
Publicado: (1979)

Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair
por: Murphy, Christopher L, et al.
Publicado: (2009)

Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy
por: Griffiths, R W, et al.
Publicado: (2005)

Expression of oncofoetal pancreatic antigens in hamster adult pancreas during experimental carcinogenesis.
por: Escribano, M. J., et al.
Publicado: (1985)

Unsatisfactory quality of E. coli asparaginase biogenerics in India: Implications for clinical outcomes in acute lymphoblastic leukaemia
por: Sidhu, Jasmeet, et al.
Publicado: (2021)

Comparative treatment costs of risk‐stratified therapy for childhood acute lymphoblastic leukemia in India
por: Mungle, Tushar, et al.
Publicado: (2022)

5T4 oncofoetal glycoprotein: an old target for a novel prostate cancer immunotherapy
por: Cappuccini, Federica, et al.
Publicado: (2017)

Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
por: Stevens, R. H., et al.
Publicado: (1981)

Temporal changes in incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council Trials, 1985–2001
por: Krishnan, Shekhar, et al.
Publicado: (2009)

Oncofoetal fibronectin – a tumour-specific marker in detecting minimal residual disease in differentiated thyroid carcinoma
por: Hesse, E, et al.
Publicado: (2005)

Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6–LYN gene fusion
por: Telford, N, et al.
Publicado: (2016)

Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia
por: Liu, Jizhong, et al.
Publicado: (2015)

A phase II study of a 5T4 oncofoetal antigen tumour-targeted superantigen (ABR-214936) therapy in patients with advanced renal cell carcinoma
por: Shaw, D M, et al.
Publicado: (2007)

Thymus-Derived, Peripherally Derived, and in vitro-Induced T Regulatory Cells
por: Elkord, Eyad
Publicado: (2014)

Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios(+) and Helios(−) Cells Coexist within the Natural FOXP3(+) T Regulatory Cell Subset in Humans
por: Elkord, Eyad
Publicado: (2016)

Outcomes of patients with childhood B-cell precursor acute lymphoblastic leukaemia with late bone marrow relapses: long-term follow-up of the ALLR3 open-label randomised trial
por: Parker, Catriona, et al.
Publicado: (2019)

SOX7 promotes the maintenance and proliferation of B cell precursor acute lymphoblastic cells
por: Cuvertino, Sara, et al.
Publicado: (2016)

Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment
por: Nowak-Sliwinska, Patrycja, et al.
Publicado: (2018)

Acute lymphoblastic leukaemia cells produce large extracellular vesicles containing organelles and an active cytoskeleton
por: Johnson, Suzanne M., et al.
Publicado: (2017)

Chemotactic self-caging in active emulsions
por: Hokmabad, Babak Vajdi, et al.
Publicado: (2022)

CXCR4 Mediated Chemotaxis Is Regulated by 5T4 Oncofetal Glycoprotein in Mouse Embryonic Cells
por: Southgate, Thomas D., et al.
Publicado: (2010)

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity
por: Jaggupilli, Appalaraju, et al.
Publicado: (2012)

Downregulation of Immunosuppressive Environment in Patients with Chronic HBV Hepatitis on Maintained Remission
por: Chaudhary, Belal, et al.
Publicado: (2015)

Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting
por: Chaudhary, Belal, et al.
Publicado: (2016)

Exosomes: Biological Carriers and Promising Tools for Cancer Immunotherapy
por: Saleh, Reem, et al.
Publicado: (2020)

Promising use of immune cell‐derived exosomes in the treatment of SARS‐CoV‐2 infections
por: Alahdal, Murad, et al.
Publicado: (2022)

Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities
por: Alahdal, Murad, et al.
Publicado: (2022)

Non‐coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
por: Alahdal, Murad, et al.
Publicado: (2023)

Cross-presentation of the oncofoetal tumor antigen 5T4 from irradiated prostate cancer cells - a key role for Hsp70
por: Salimu, Josephine C, et al.
Publicado: (2014)

Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers
por: Toor, Salman M., et al.
Publicado: (2017)

T-Regulatory Cells in Health and Disease
por: Elkord, Eyad, et al.
Publicado: (2018)

Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α
por: Elkord, Eyad, et al.
Publicado: (2015)

Outcome of Central Nervous System Relapses In Childhood Acute Lymphoblastic Leukaemia – Prospective Open Cohort Analyses of the ALLR3 Trial
por: Masurekar, Ashish Narayan, et al.
Publicado: (2014)

Decoding the chemotactic signal
por: Thomas, Monica A., et al.
Publicado: (2018)

The cost-effectiveness of pegaspargase versus native asparaginase for first-line treatment of acute lymphoblastic leukaemia: a UK-based cost-utility analysis
por: Hu, Xingdi, et al.
Publicado: (2019)

Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India
por: Das, Nandana, et al.
Publicado: (2022)

C6: A Monoclonal Antibody Specific for a Fibronectin Epitope Situated at the Interface between the Oncofoetal Extra-Domain B and the Repeat III8
por: Ventura, Elisa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_13fnfm28odtuutcl9i42olmfek