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MRSA epidemic linked to a quickly spreading colonization and virulence determinant
The molecular processes underlying epidemic waves of methicillin-resistant Staphylococcus aureus (MRSA) are poorly understood(1). While a major role has been attributed to the acquisition of virulence determinants by horizontal gene transfer(2), there are insufficient epidemiological and functional...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378817/ https://www.ncbi.nlm.nih.gov/pubmed/22522561 http://dx.doi.org/10.1038/nm.2692 |
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author | Li, Min Du, Xin Villaruz, Amer E. Diep, Binh An Wang, Decheng Song, Yan Tian, Yueru Hu, Jinhui Yu, Fangyou Lu, Yuan Otto, Michael |
author_facet | Li, Min Du, Xin Villaruz, Amer E. Diep, Binh An Wang, Decheng Song, Yan Tian, Yueru Hu, Jinhui Yu, Fangyou Lu, Yuan Otto, Michael |
author_sort | Li, Min |
collection | PubMed |
description | The molecular processes underlying epidemic waves of methicillin-resistant Staphylococcus aureus (MRSA) are poorly understood(1). While a major role has been attributed to the acquisition of virulence determinants by horizontal gene transfer(2), there are insufficient epidemiological and functional data supporting that concept. We here report the spread of clones containing a previously extremely rare(3,4) mobile genetic element-encoded gene, sasX. We demonstrate that sasX has a key role in MRSA colonization and pathogenesis, significantly enhancing nasal colonization, lung disease, and abscess formation, and promoting mechanisms of immune evasion. Moreover, we observed the recent spread of sasX from sequence type (ST) 239 to invasive clones belonging to other STs. Our study identifies sasX as a quickly spreading critical determinant of MRSA pathogenic success and a promising target for therapeutic interference. Importantly, our results provide proof-of-principle that horizontal gene transfer of key virulence determinants drives MRSA epidemic waves. |
format | Online Article Text |
id | pubmed-3378817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-33788172012-11-01 MRSA epidemic linked to a quickly spreading colonization and virulence determinant Li, Min Du, Xin Villaruz, Amer E. Diep, Binh An Wang, Decheng Song, Yan Tian, Yueru Hu, Jinhui Yu, Fangyou Lu, Yuan Otto, Michael Nat Med Article The molecular processes underlying epidemic waves of methicillin-resistant Staphylococcus aureus (MRSA) are poorly understood(1). While a major role has been attributed to the acquisition of virulence determinants by horizontal gene transfer(2), there are insufficient epidemiological and functional data supporting that concept. We here report the spread of clones containing a previously extremely rare(3,4) mobile genetic element-encoded gene, sasX. We demonstrate that sasX has a key role in MRSA colonization and pathogenesis, significantly enhancing nasal colonization, lung disease, and abscess formation, and promoting mechanisms of immune evasion. Moreover, we observed the recent spread of sasX from sequence type (ST) 239 to invasive clones belonging to other STs. Our study identifies sasX as a quickly spreading critical determinant of MRSA pathogenic success and a promising target for therapeutic interference. Importantly, our results provide proof-of-principle that horizontal gene transfer of key virulence determinants drives MRSA epidemic waves. 2012-05 /pmc/articles/PMC3378817/ /pubmed/22522561 http://dx.doi.org/10.1038/nm.2692 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Li, Min Du, Xin Villaruz, Amer E. Diep, Binh An Wang, Decheng Song, Yan Tian, Yueru Hu, Jinhui Yu, Fangyou Lu, Yuan Otto, Michael MRSA epidemic linked to a quickly spreading colonization and virulence determinant |
title | MRSA epidemic linked to a quickly spreading colonization and virulence determinant |
title_full | MRSA epidemic linked to a quickly spreading colonization and virulence determinant |
title_fullStr | MRSA epidemic linked to a quickly spreading colonization and virulence determinant |
title_full_unstemmed | MRSA epidemic linked to a quickly spreading colonization and virulence determinant |
title_short | MRSA epidemic linked to a quickly spreading colonization and virulence determinant |
title_sort | mrsa epidemic linked to a quickly spreading colonization and virulence determinant |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378817/ https://www.ncbi.nlm.nih.gov/pubmed/22522561 http://dx.doi.org/10.1038/nm.2692 |
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