Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

We report here the 1.62 Å crystal structure of an intramolecular quadruplex DNA formed from a sequence in the promoter region of the c-kit gene. This is the first reported crystal structure of a promoter quadruplex and the first observation of localized magnesium ions in a quadruplex structure. The...

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Detalles Bibliográficos
Autores principales: Wei, Dengguo, Parkinson, Gary N., Reszka, Anthony P., Neidle, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378867/
https://www.ncbi.nlm.nih.gov/pubmed/22287624
http://dx.doi.org/10.1093/nar/gks023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378867/
https://www.ncbi.nlm.nih.gov/pubmed/22287624
http://dx.doi.org/10.1093/nar/gks023

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