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Biogenesis of mammalian microRNAs by a non-canonical processing pathway

Canonical microRNA biogenesis requires the Microprocessor components, Drosha and DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The Microprocessor is not required for processing of some miRNAs, including mirtrons, in which spliceosome-excised introns are direct Dicer substrates....

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Detalles Bibliográficos
Autores principales:	Havens, Mallory A., Reich, Ashley A., Duelli, Dominik M., Hastings, Michelle L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378869/ https://www.ncbi.nlm.nih.gov/pubmed/22270084 http://dx.doi.org/10.1093/nar/gks026

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