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Analysis of MRE11's function in the 5′→3′ processing of DNA double-strand breaks

The resection of DNA double-strand breaks (DSBs) into 3′ single-strand tails is the initiating step of homology-dependent repair pathways. A key player in this process is the MRE11-RAD50-NBS1 complex, but its contribution to and mechanistic role in resection are not well understood. In this study, w...

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Detalles Bibliográficos
Autores principales:	Liao, Shuren, Guay, Catherine, Toczylowski, Thomas, Yan, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378884/ https://www.ncbi.nlm.nih.gov/pubmed/22319209 http://dx.doi.org/10.1093/nar/gks044

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