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DNA polymerase zeta is required for proliferation of normal mammalian cells

Unique among translesion synthesis (TLS) DNA polymerases, pol ζ is essential during embryogenesis. To determine whether pol ζ is necessary for proliferation of normal cells, primary mouse fibroblasts were established in which Rev3L could be conditionally inactivated by Cre recombinase. Cells were gr...

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Detalles Bibliográficos
Autores principales:	Lange, Sabine S., Wittschieben, John P., Wood, Richard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378892/ https://www.ncbi.nlm.nih.gov/pubmed/22319213 http://dx.doi.org/10.1093/nar/gks054

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