Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate

The reaction between methyl (R)-2-(2-chloro­phen­yl)-2-hy­droxy­acetate and 3-nitro­benzene­sulfonyl chloride gave the title compound, C(15)H(12)ClNO(7)S, which is a promising inter­mediate for the synthesis of Clopidrogel, an anti­platelet drug used in the prevention of strokes and heart attacks. I...

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Detalles Bibliográficos
Autores principales: Li, Ying-Hua, Xu, Hong-Wu, Zhang, Liu-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379285/
https://www.ncbi.nlm.nih.gov/pubmed/22719483
http://dx.doi.org/10.1107/S1600536812020016
Descripción
Sumario:The reaction between methyl (R)-2-(2-chloro­phen­yl)-2-hy­droxy­acetate and 3-nitro­benzene­sulfonyl chloride gave the title compound, C(15)H(12)ClNO(7)S, which is a promising inter­mediate for the synthesis of Clopidrogel, an anti­platelet drug used in the prevention of strokes and heart attacks. In the crystal, mol­ecules are linked through C—H⋯O interactions, and there is also a short Cl⋯O contact present [Cl⋯O = 3.018 (2) Å].

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