Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate

The reaction between methyl (R)-2-(2-chloro­phen­yl)-2-hy­droxy­acetate and 3-nitro­benzene­sulfonyl chloride gave the title compound, C(15)H(12)ClNO(7)S, which is a promising inter­mediate for the synthesis of Clopidrogel, an anti­platelet drug used in the prevention of strokes and heart attacks. I...

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Detalles Bibliográficos
Autores principales: Li, Ying-Hua, Xu, Hong-Wu, Zhang, Liu-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379285/
https://www.ncbi.nlm.nih.gov/pubmed/22719483
http://dx.doi.org/10.1107/S1600536812020016
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author Li, Ying-Hua
Xu, Hong-Wu
Zhang, Liu-Xue
author_facet Li, Ying-Hua
Xu, Hong-Wu
Zhang, Liu-Xue
author_sort Li, Ying-Hua
collection PubMed
description The reaction between methyl (R)-2-(2-chloro­phen­yl)-2-hy­droxy­acetate and 3-nitro­benzene­sulfonyl chloride gave the title compound, C(15)H(12)ClNO(7)S, which is a promising inter­mediate for the synthesis of Clopidrogel, an anti­platelet drug used in the prevention of strokes and heart attacks. In the crystal, mol­ecules are linked through C—H⋯O interactions, and there is also a short Cl⋯O contact present [Cl⋯O = 3.018 (2) Å].
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spelling pubmed-33792852012-06-20 Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate Li, Ying-Hua Xu, Hong-Wu Zhang, Liu-Xue Acta Crystallogr Sect E Struct Rep Online Organic Papers The reaction between methyl (R)-2-(2-chloro­phen­yl)-2-hy­droxy­acetate and 3-nitro­benzene­sulfonyl chloride gave the title compound, C(15)H(12)ClNO(7)S, which is a promising inter­mediate for the synthesis of Clopidrogel, an anti­platelet drug used in the prevention of strokes and heart attacks. In the crystal, mol­ecules are linked through C—H⋯O interactions, and there is also a short Cl⋯O contact present [Cl⋯O = 3.018 (2) Å]. International Union of Crystallography 2012-05-12 /pmc/articles/PMC3379285/ /pubmed/22719483 http://dx.doi.org/10.1107/S1600536812020016 Text en © Li et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Li, Ying-Hua
Xu, Hong-Wu
Zhang, Liu-Xue
Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate
title Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate
title_full Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate
title_fullStr Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate
title_full_unstemmed Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate
title_short Methyl (R)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate
title_sort methyl (r)-2-(2-chloro­phen­yl)-2-(3-nitro­phenyl­sulfon­yloxy)acetate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379285/
https://www.ncbi.nlm.nih.gov/pubmed/22719483
http://dx.doi.org/10.1107/S1600536812020016
work_keys_str_mv AT liyinghua methylr22chlorophenyl23nitrophenylsulfonyloxyacetate
AT xuhongwu methylr22chlorophenyl23nitrophenylsulfonyloxyacetate
AT zhangliuxue methylr22chlorophenyl23nitrophenylsulfonyloxyacetate

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