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5-[(4-Eth­oxy­anilino)meth­yl]-N-(2-fluoro­phen­yl)-6-methyl-2-phenyl­pyrimidin-4-amine

The asymmetric unit of the title compound, C(26)H(25)FN(4)O, consists of two symmetry-independent mol­ecules, denoted A and B. The conformation of each mol­ecule is mainly determined by an intra­molecular N—H⋯N hydrogen bond, which closes a six-membered ring. The dihedral angles between the pyrimidi...

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Detalles Bibliográficos
Autores principales: Cieplik, Jerzy, Stolarczyk, Marcin, Bryndal, Iwona, Lis, Tadeusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379319/
https://www.ncbi.nlm.nih.gov/pubmed/22719517
http://dx.doi.org/10.1107/S1600536812021046
Descripción
Sumario:The asymmetric unit of the title compound, C(26)H(25)FN(4)O, consists of two symmetry-independent mol­ecules, denoted A and B. The conformation of each mol­ecule is mainly determined by an intra­molecular N—H⋯N hydrogen bond, which closes a six-membered ring. The dihedral angles between the pyrimidine ring and the phenyl, fluorophenyl and ethoxyphenyl rings are 15.4 (2), 28.4 (2) and 77.5 (2)°, respectively, in mol­ecule A, and 15.9 (2), 2.7 (2) and 61.8 (2)° in mol­ecule B. Inter­molecular N—H⋯N hydrogen bonds and π–π stacking inter­actions between pyrimidine rings [centroid–centroid distance = 3.692 (4) Å] connect mol­ecules A and B into dimers and C—H⋯O hydrogen bonds link the dimers into zigzag chains along [011]. The (4-eth­oxy­anilino)methyl group of the B mol­ecule is disordered over two sets of sites, the occupancy factor for the major component being 0.900 (2).