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3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide
In the title compound, C(21)H(16)FN(3)OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57 (12) and 83.87 (5)° with the fluorophenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, molecules are linked by weak N—H⋯N anf N—H⋯O hydrogen bo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379397/ https://www.ncbi.nlm.nih.gov/pubmed/22719595 http://dx.doi.org/10.1107/S160053681202212X |
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author | Zhao, Jin-Ni Yang, Sheng-Yong Yang, Li |
author_facet | Zhao, Jin-Ni Yang, Sheng-Yong Yang, Li |
author_sort | Zhao, Jin-Ni |
collection | PubMed |
description | In the title compound, C(21)H(16)FN(3)OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57 (12) and 83.87 (5)° with the fluorophenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, molecules are linked by weak N—H⋯N anf N—H⋯O hydrogen bonds and π–π stacking interactions involving fluorophenyl rings of adjacent molecules, with a centroid–centroid distance of 3.648 (10) Å. In addition, intramolecular N—H⋯S and N—H⋯O hydrogen bonds contribute to the stability of the molecular conformation. |
format | Online Article Text |
id | pubmed-3379397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-33793972012-06-20 3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide Zhao, Jin-Ni Yang, Sheng-Yong Yang, Li Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(21)H(16)FN(3)OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57 (12) and 83.87 (5)° with the fluorophenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, molecules are linked by weak N—H⋯N anf N—H⋯O hydrogen bonds and π–π stacking interactions involving fluorophenyl rings of adjacent molecules, with a centroid–centroid distance of 3.648 (10) Å. In addition, intramolecular N—H⋯S and N—H⋯O hydrogen bonds contribute to the stability of the molecular conformation. International Union of Crystallography 2012-05-19 /pmc/articles/PMC3379397/ /pubmed/22719595 http://dx.doi.org/10.1107/S160053681202212X Text en © Zhao et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Zhao, Jin-Ni Yang, Sheng-Yong Yang, Li 3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide |
title | 3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide |
title_full | 3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide |
title_fullStr | 3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide |
title_full_unstemmed | 3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide |
title_short | 3-Amino-N-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide |
title_sort | 3-amino-n-benzyl-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379397/ https://www.ncbi.nlm.nih.gov/pubmed/22719595 http://dx.doi.org/10.1107/S160053681202212X |
work_keys_str_mv | AT zhaojinni 3aminonbenzyl64fluorophenylthieno23bpyridine2carboxamide AT yangshengyong 3aminonbenzyl64fluorophenylthieno23bpyridine2carboxamide AT yangli 3aminonbenzyl64fluorophenylthieno23bpyridine2carboxamide |