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3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide

In the title compound, C(21)H(16)FN(3)OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57 (12) and 83.87 (5)° with the fluoro­phenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, mol­ecules are linked by weak N—H⋯N anf N—H⋯O hydrogen bo...

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Detalles Bibliográficos
Autores principales: Zhao, Jin-Ni, Yang, Sheng-Yong, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379397/
https://www.ncbi.nlm.nih.gov/pubmed/22719595
http://dx.doi.org/10.1107/S160053681202212X
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author Zhao, Jin-Ni
Yang, Sheng-Yong
Yang, Li
author_facet Zhao, Jin-Ni
Yang, Sheng-Yong
Yang, Li
author_sort Zhao, Jin-Ni
collection PubMed
description In the title compound, C(21)H(16)FN(3)OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57 (12) and 83.87 (5)° with the fluoro­phenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, mol­ecules are linked by weak N—H⋯N anf N—H⋯O hydrogen bonds and π–π stacking inter­actions involving fluoro­phenyl rings of adjacent mol­ecules, with a centroid–centroid distance of 3.648 (10) Å. In addition, intra­molecular N—H⋯S and N—H⋯O hydrogen bonds contribute to the stability of the mol­ecular conformation.
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spelling pubmed-33793972012-06-20 3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide Zhao, Jin-Ni Yang, Sheng-Yong Yang, Li Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(21)H(16)FN(3)OS, the thieno[2,3-b]pyridine system forms dihedral angles of 10.57 (12) and 83.87 (5)° with the fluoro­phenyl ring at the 6-position and the phenyl ring of the benzyl group, respectively. In the crystal, mol­ecules are linked by weak N—H⋯N anf N—H⋯O hydrogen bonds and π–π stacking inter­actions involving fluoro­phenyl rings of adjacent mol­ecules, with a centroid–centroid distance of 3.648 (10) Å. In addition, intra­molecular N—H⋯S and N—H⋯O hydrogen bonds contribute to the stability of the mol­ecular conformation. International Union of Crystallography 2012-05-19 /pmc/articles/PMC3379397/ /pubmed/22719595 http://dx.doi.org/10.1107/S160053681202212X Text en © Zhao et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Zhao, Jin-Ni
Yang, Sheng-Yong
Yang, Li
3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide
title 3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide
title_full 3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide
title_fullStr 3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide
title_full_unstemmed 3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide
title_short 3-Amino-N-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide
title_sort 3-amino-n-benzyl-6-(4-fluoro­phen­yl)thieno[2,3-b]pyridine-2-carboxamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379397/
https://www.ncbi.nlm.nih.gov/pubmed/22719595
http://dx.doi.org/10.1107/S160053681202212X
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