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Reactive Oxygen Species Signaling Facilitates FOXO-3a/FBXO-Dependent Vascular BK Channel β(1) Subunit Degradation in Diabetic Mice

Activity of the vascular large conductance Ca(2+)-activated K(+) (BK) channel is tightly regulated by its accessory β(1) subunit (BK-β(1)). Downregulation of BK-β(1) expression in diabetic vessels is associated with upregulation of the forkhead box O subfamily transcription factor-3a (FOXO-3a)–depen...

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Detalles Bibliográficos
Autores principales:	Lu, Tong, Chai, Qiang, Yu, Ling, d’Uscio, Livius V., Katusic, Zvonimir S., He, Tongrong, Lee, Hon-Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379647/ https://www.ncbi.nlm.nih.gov/pubmed/22586590 http://dx.doi.org/10.2337/db11-1658

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