Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

Vascular dysfunction that accompanies obesity and insulin resistance may be mediated by lipid metabolites. We sought to determine if vascular ceramide leads to arterial dysfunction and to elucidate the underlying mechanisms. Pharmacological inhibition of de novo ceramide synthesis, using the Ser pal...

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Detalles Bibliográficos
Autores principales: Zhang, Quan-Jiang, Holland, William L., Wilson, Lloyd, Tanner, Jason M., Kearns, Devin, Cahoon, Judd M., Pettey, Dix, Losee, Jason, Duncan, Bradlee, Gale, Derrick, Kowalski, Christopher A., Deeter, Nicholas, Nichols, Alexandrea, Deesing, Michole, Arrant, Colton, Ruan, Ting, Boehme, Christoph, McCamey, Dane R., Rou, Janvida, Ambal, Kapil, Narra, Krishna K., Summers, Scott A., Abel, E. Dale, Symons, J. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379648/
https://www.ncbi.nlm.nih.gov/pubmed/22586587
http://dx.doi.org/10.2337/db11-1399

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