Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

Insulin is secreted from the islets of Langerhans in coordinated pulses. These pulses are thought to lead to plasma insulin oscillations, which are putatively more effective in lowering blood glucose than continuous levels of insulin. Gap-junction coupling of β-cells by connexin-36 coordinates intra...

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Detalles Bibliográficos
Autores principales: Head, W. Steven, Orseth, Meredith L., Nunemaker, Craig S., Satin, Leslie S., Piston, David W., Benninger, Richard K.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379660/
https://www.ncbi.nlm.nih.gov/pubmed/22511206
http://dx.doi.org/10.2337/db11-1312

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