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Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes

The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secretory, biophysical, and ultrastructural features in...

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Detalles Bibliográficos
Autores principales:	Rosengren, Anders H., Braun, Matthias, Mahdi, Taman, Andersson, Sofia A., Travers, Mary E., Shigeto, Makoto, Zhang, Enming, Almgren, Peter, Ladenvall, Claes, Axelsson, Annika S., Edlund, Anna, Pedersen, Morten Gram, Jonsson, Anna, Ramracheya, Reshma, Tang, Yunzhao, Walker, Jonathan N., Barrett, Amy, Johnson, Paul R.V., Lyssenko, Valeriya, McCarthy, Mark I., Groop, Leif, Salehi, Albert, Gloyn, Anna L., Renström, Erik, Rorsman, Patrik, Eliasson, Lena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379663/ https://www.ncbi.nlm.nih.gov/pubmed/22492527 http://dx.doi.org/10.2337/db11-1516

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