In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Focal adhesion kinase (FAK) acts as an adaptor at the focal contacts serving as a junction between the extracellular matrix and actin cytoskeleton. Actin dynamics is known as a determinant step in insulin secretion. Additionally, FAK has been shown to regulate insulin signaling. To investigate the e...

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Detalles Bibliográficos
Autores principales: Cai, Erica P., Casimir, Marina, Schroer, Stephanie A., Luk, Cynthia T., Shi, Sally Yu, Choi, Diana, Dai, Xiao Qing, Hajmrle, Catherine, Spigelman, Aliya F., Zhu, Dan, Gaisano, Herbert Y., MacDonald, Patrick E., Woo, Minna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379666/
https://www.ncbi.nlm.nih.gov/pubmed/22498697
http://dx.doi.org/10.2337/db11-1344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379666/
https://www.ncbi.nlm.nih.gov/pubmed/22498697
http://dx.doi.org/10.2337/db11-1344

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