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Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables
Cognitive functioning depends on intact brain networks that can be assessed with functional magnetic resonance imaging (fMRI) techniques. We hypothesized that cognitive decrements in type 1 diabetes mellitus (T1DM) are associated with alterations in resting-state neural connectivity and that these c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379683/ https://www.ncbi.nlm.nih.gov/pubmed/22438575 http://dx.doi.org/10.2337/db11-1358 |
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author | van Duinkerken, Eelco Schoonheim, Menno M. Sanz-Arigita, Ernesto J. IJzerman, Richard G. Moll, Annette C. Snoek, Frank J. Ryan, Christopher M. Klein, Martin Diamant, Michaela Barkhof, Frederik |
author_facet | van Duinkerken, Eelco Schoonheim, Menno M. Sanz-Arigita, Ernesto J. IJzerman, Richard G. Moll, Annette C. Snoek, Frank J. Ryan, Christopher M. Klein, Martin Diamant, Michaela Barkhof, Frederik |
author_sort | van Duinkerken, Eelco |
collection | PubMed |
description | Cognitive functioning depends on intact brain networks that can be assessed with functional magnetic resonance imaging (fMRI) techniques. We hypothesized that cognitive decrements in type 1 diabetes mellitus (T1DM) are associated with alterations in resting-state neural connectivity and that these changes vary according to the degree of microangiopathy. T1DM patients with (MA(+): n = 49) and without (MA(−): n = 52) microangiopathy were compared with 48 healthy control subjects. All completed a neuropsychological assessment and resting-state fMRI. Networks were identified using multisubject independent component analysis; specific group differences within each network were analyzed using the dual-regression method, corrected for confounding factors and multiple comparisons. Relative to control subjects, MA(−) patients showed increased connectivity in networks involved in motor and visual processes, whereas MA(+) patients showed decreased connectivity in networks involving attention, working memory, auditory and language processing, and motor and visual processes. Better information-processing speed and general cognitive ability were related to increased degree of connectivity. T1DM is associated with a functional reorganization of neural networks that varies, dependent on the presence or absence of microangiopathy. |
format | Online Article Text |
id | pubmed-3379683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-33796832013-07-01 Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables van Duinkerken, Eelco Schoonheim, Menno M. Sanz-Arigita, Ernesto J. IJzerman, Richard G. Moll, Annette C. Snoek, Frank J. Ryan, Christopher M. Klein, Martin Diamant, Michaela Barkhof, Frederik Diabetes Complications Cognitive functioning depends on intact brain networks that can be assessed with functional magnetic resonance imaging (fMRI) techniques. We hypothesized that cognitive decrements in type 1 diabetes mellitus (T1DM) are associated with alterations in resting-state neural connectivity and that these changes vary according to the degree of microangiopathy. T1DM patients with (MA(+): n = 49) and without (MA(−): n = 52) microangiopathy were compared with 48 healthy control subjects. All completed a neuropsychological assessment and resting-state fMRI. Networks were identified using multisubject independent component analysis; specific group differences within each network were analyzed using the dual-regression method, corrected for confounding factors and multiple comparisons. Relative to control subjects, MA(−) patients showed increased connectivity in networks involved in motor and visual processes, whereas MA(+) patients showed decreased connectivity in networks involving attention, working memory, auditory and language processing, and motor and visual processes. Better information-processing speed and general cognitive ability were related to increased degree of connectivity. T1DM is associated with a functional reorganization of neural networks that varies, dependent on the presence or absence of microangiopathy. American Diabetes Association 2012-07 2012-06-15 /pmc/articles/PMC3379683/ /pubmed/22438575 http://dx.doi.org/10.2337/db11-1358 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Complications van Duinkerken, Eelco Schoonheim, Menno M. Sanz-Arigita, Ernesto J. IJzerman, Richard G. Moll, Annette C. Snoek, Frank J. Ryan, Christopher M. Klein, Martin Diamant, Michaela Barkhof, Frederik Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables |
title | Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables |
title_full | Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables |
title_fullStr | Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables |
title_full_unstemmed | Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables |
title_short | Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables |
title_sort | resting-state brain networks in type 1 diabetic patients with and without microangiopathy and their relation to cognitive functions and disease variables |
topic | Complications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379683/ https://www.ncbi.nlm.nih.gov/pubmed/22438575 http://dx.doi.org/10.2337/db11-1358 |
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