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Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting

AIMS: The study aimed to compare the frequency of neuropsychiatric symptoms (NPS) across the declining memory continuum, from normal aging, subjective cognitive impairment (SCI), and mild cognitive impairment (MCI) to Alzheimer's disease (AD), and to explore the clinical correlates of NPS. METH...

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Autores principales: Zhang, Meiyan, Wang, Huali, Li, Tao, Yu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379732/
https://www.ncbi.nlm.nih.gov/pubmed/22719746
http://dx.doi.org/10.1159/000338410
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author Zhang, Meiyan
Wang, Huali
Li, Tao
Yu, Xin
author_facet Zhang, Meiyan
Wang, Huali
Li, Tao
Yu, Xin
author_sort Zhang, Meiyan
collection PubMed
description AIMS: The study aimed to compare the frequency of neuropsychiatric symptoms (NPS) across the declining memory continuum, from normal aging, subjective cognitive impairment (SCI), and mild cognitive impairment (MCI) to Alzheimer's disease (AD), and to explore the clinical correlates of NPS. METHOD: In a memory clinic, 157 subjects (46 mild AD patients, 38 MCI individuals, 24 SCI subjects, and 49 normal controls) completed the neurobehavioral assessments with the Neuropsychiatric Inventory (NPI). The clinical significance of each NPI domain was defined as an item score ≥4. Result: Clinically significant depression was more common in the SCI than in the normal control group (p < 0.05). The frequency of NPS was significantly greater in the mild AD group compared to other groups. Clinically significant apathy and aberrant motor behavior were more common among the AD group than the MCI group (p < 0.05). The MMSE score (OR 4.84, 95% CI 1.92–12.16, p = 0.001) and apathy (OR 12.73, 95% CI 1.48–109.68, p = 0.021) significantly determined the diagnostic status as MCI or mild AD. CONCLUSION: Across the declining memory continuum, the frequency of NPS was highest among mild AD patients. Depression, apathy, and aberrant motor behavior deserve more attention. Presence of apathy might be an independent determinant for mild AD.
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spelling pubmed-33797322012-06-20 Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting Zhang, Meiyan Wang, Huali Li, Tao Yu, Xin Dement Geriatr Cogn Dis Extra Original Research Article AIMS: The study aimed to compare the frequency of neuropsychiatric symptoms (NPS) across the declining memory continuum, from normal aging, subjective cognitive impairment (SCI), and mild cognitive impairment (MCI) to Alzheimer's disease (AD), and to explore the clinical correlates of NPS. METHOD: In a memory clinic, 157 subjects (46 mild AD patients, 38 MCI individuals, 24 SCI subjects, and 49 normal controls) completed the neurobehavioral assessments with the Neuropsychiatric Inventory (NPI). The clinical significance of each NPI domain was defined as an item score ≥4. Result: Clinically significant depression was more common in the SCI than in the normal control group (p < 0.05). The frequency of NPS was significantly greater in the mild AD group compared to other groups. Clinically significant apathy and aberrant motor behavior were more common among the AD group than the MCI group (p < 0.05). The MMSE score (OR 4.84, 95% CI 1.92–12.16, p = 0.001) and apathy (OR 12.73, 95% CI 1.48–109.68, p = 0.021) significantly determined the diagnostic status as MCI or mild AD. CONCLUSION: Across the declining memory continuum, the frequency of NPS was highest among mild AD patients. Depression, apathy, and aberrant motor behavior deserve more attention. Presence of apathy might be an independent determinant for mild AD. S. Karger AG 2012-04-27 /pmc/articles/PMC3379732/ /pubmed/22719746 http://dx.doi.org/10.1159/000338410 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Original Research Article
Zhang, Meiyan
Wang, Huali
Li, Tao
Yu, Xin
Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting
title Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting
title_full Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting
title_fullStr Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting
title_full_unstemmed Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting
title_short Prevalence of Neuropsychiatric Symptoms across the Declining Memory Continuum: An Observational Study in a Memory Clinic Setting
title_sort prevalence of neuropsychiatric symptoms across the declining memory continuum: an observational study in a memory clinic setting
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379732/
https://www.ncbi.nlm.nih.gov/pubmed/22719746
http://dx.doi.org/10.1159/000338410
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