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Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets

The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with highly conserved human homologs may represent a promising reservoir of new potential drug targets. The cyclic nucleotide-specific phosphodiestera...

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Detalles Bibliográficos
Autores principales:	de Koning, Harry P., Gould, Matthew K., Sterk, Geert Jan, Tenor, Hermann, Kunz, Stefan, Luginbuehl, Edith, Seebeck, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379837/ https://www.ncbi.nlm.nih.gov/pubmed/22291195 http://dx.doi.org/10.1093/infdis/jir857

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