Cargando…
Pediatric ulcerative colitis: current treatment approaches including role of infliximab
Ulcerative colitis is a chronic inflammatory bowel disease that can lead to derangements in the growth, nutritional status, and psychosocial development of affected children. There are several medical options for the induction and maintenance of disease remission, but the benefits of these medicatio...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379853/ https://www.ncbi.nlm.nih.gov/pubmed/22740771 http://dx.doi.org/10.2147/BTT.S31833 |
_version_ | 1782236251149041664 |
---|---|
author | Bradley, Gia M Oliva-Hemker, Maria |
author_facet | Bradley, Gia M Oliva-Hemker, Maria |
author_sort | Bradley, Gia M |
collection | PubMed |
description | Ulcerative colitis is a chronic inflammatory bowel disease that can lead to derangements in the growth, nutritional status, and psychosocial development of affected children. There are several medical options for the induction and maintenance of disease remission, but the benefits of these medications need to be carefully weighed against the risks, especially in the pediatric population. As the etiology of the disease has become increasingly understood, newer therapeutic alternatives have arisen in the form of biologic therapies, which are monoclonal antibodies targeted to a specific protein or receptor. This review will discuss the classical treatments for children with ulcerative colitis, including 5-aminosalicylates, corticosteroids, thiopurine immunomodulators, and calcineurin inhibitors, with a particular focus on the newer class of anti-tumor necrosis factor-α agents. |
format | Online Article Text |
id | pubmed-3379853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33798532012-06-27 Pediatric ulcerative colitis: current treatment approaches including role of infliximab Bradley, Gia M Oliva-Hemker, Maria Biologics Review Ulcerative colitis is a chronic inflammatory bowel disease that can lead to derangements in the growth, nutritional status, and psychosocial development of affected children. There are several medical options for the induction and maintenance of disease remission, but the benefits of these medications need to be carefully weighed against the risks, especially in the pediatric population. As the etiology of the disease has become increasingly understood, newer therapeutic alternatives have arisen in the form of biologic therapies, which are monoclonal antibodies targeted to a specific protein or receptor. This review will discuss the classical treatments for children with ulcerative colitis, including 5-aminosalicylates, corticosteroids, thiopurine immunomodulators, and calcineurin inhibitors, with a particular focus on the newer class of anti-tumor necrosis factor-α agents. Dove Medical Press 2012 2012-06-05 /pmc/articles/PMC3379853/ /pubmed/22740771 http://dx.doi.org/10.2147/BTT.S31833 Text en © 2012 Bradley and Oliva-Hemker, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Bradley, Gia M Oliva-Hemker, Maria Pediatric ulcerative colitis: current treatment approaches including role of infliximab |
title | Pediatric ulcerative colitis: current treatment approaches including role of infliximab |
title_full | Pediatric ulcerative colitis: current treatment approaches including role of infliximab |
title_fullStr | Pediatric ulcerative colitis: current treatment approaches including role of infliximab |
title_full_unstemmed | Pediatric ulcerative colitis: current treatment approaches including role of infliximab |
title_short | Pediatric ulcerative colitis: current treatment approaches including role of infliximab |
title_sort | pediatric ulcerative colitis: current treatment approaches including role of infliximab |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379853/ https://www.ncbi.nlm.nih.gov/pubmed/22740771 http://dx.doi.org/10.2147/BTT.S31833 |
work_keys_str_mv | AT bradleygiam pediatriculcerativecolitiscurrenttreatmentapproachesincludingroleofinfliximab AT olivahemkermaria pediatriculcerativecolitiscurrenttreatmentapproachesincludingroleofinfliximab |