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Structural organization of brain-derived mammalian prions as probed by hydrogen exchange

One of the mysteries in prion research is the structure of the infectious form of mammalian prion protein, PrP(Sc). We used MS analysis of H/D exchange to examine brain-derived PrP(Sc). Our data indicate that, contrary to popular models, prion protein conversion involves refolding of the entire regi...

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Detalles Bibliográficos
Autores principales:	Smirnovas, Vytautas, Baron, Gerald S., Offerdahl, Danielle K., Raymond, Gregory J., Caughey, Byron, Surewicz, Witold K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379881/ https://www.ncbi.nlm.nih.gov/pubmed/21441913 http://dx.doi.org/10.1038/nsmb.2035

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