Activating KIR/HLA complexes in classic Kaposi's Sarcoma

BACKGROUND: Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. OBJECTIVE: We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in K...

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Detalles Bibliográficos
Autores principales: Guerini, Franca R, Mancuso, Roberta, Agostini, Simone, Agliardi, Cristina, Zanzottera, Milena, Hernis, Ambra, Tourlaki, Athanasia, Calvo, Maria G, Bellinvia, Monica, Brambilla, Lucia, Clerici, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379936/
https://www.ncbi.nlm.nih.gov/pubmed/22469025
http://dx.doi.org/10.1186/1750-9378-7-9
Descripción
Sumario:BACKGROUND: Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. OBJECTIVE: We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. METHODS: KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. RESULTS: There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. CONCLUSION: A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.

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