Cargando…
Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression
Mastocytosis is a heterogeneous disease characterized by mast cells accumulation in one or more organs. We have reported that depression is frequent in mastocytosis, but although it was already described, little is known about the prevalence and features of cognitive impairment. Our objective was to...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379977/ https://www.ncbi.nlm.nih.gov/pubmed/22745762 http://dx.doi.org/10.1371/journal.pone.0039468 |
_version_ | 1782236271848980480 |
---|---|
author | Moura, Daniela Silva Sultan, Serge Georgin-Lavialle, Sophie Barete, Stéphane Lortholary, Olivier Gaillard, Raphael Hermine, Olivier |
author_facet | Moura, Daniela Silva Sultan, Serge Georgin-Lavialle, Sophie Barete, Stéphane Lortholary, Olivier Gaillard, Raphael Hermine, Olivier |
author_sort | Moura, Daniela Silva |
collection | PubMed |
description | Mastocytosis is a heterogeneous disease characterized by mast cells accumulation in one or more organs. We have reported that depression is frequent in mastocytosis, but although it was already described, little is known about the prevalence and features of cognitive impairment. Our objective was to describe the prevalence and features of cognitive impairment in a large cohort of patients with this rare disease (n = 57; mean age = 45) and to explore the relations between memory impairment and depression. Objective memory impairment was evaluated using the 3(rd) edition of the Clinical Memory scale of Wechsler. Depression symptoms were evaluated using the Hamilton Depression Rating Scale. Age and education levels were controlled for all patients. Patients with mastocytosis presented high levels of cognitive impairment (memory and/or attention) (n = 22; 38.6%). Cognitive impairment was moderate in 59% of the cases, concerned immediate auditory (41%) and working memory (73%) and was not associated to depression (p≥0.717). In conclusion, immediate auditory memory and attention impairment in mastocytosis are frequent, even in young individuals, and are not consecutive to depression. In mastocytosis, cognitive complaints call for complex neuropsychological assessment. Mild-moderate cognitive impairment and depression constitute two specific but somewhat independent syndromes in mastocytosis. These results suggest differential effects of mast-cell activity in the brain, on systems involved in emotionality and in cognition. |
format | Online Article Text |
id | pubmed-3379977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33799772012-06-28 Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression Moura, Daniela Silva Sultan, Serge Georgin-Lavialle, Sophie Barete, Stéphane Lortholary, Olivier Gaillard, Raphael Hermine, Olivier PLoS One Research Article Mastocytosis is a heterogeneous disease characterized by mast cells accumulation in one or more organs. We have reported that depression is frequent in mastocytosis, but although it was already described, little is known about the prevalence and features of cognitive impairment. Our objective was to describe the prevalence and features of cognitive impairment in a large cohort of patients with this rare disease (n = 57; mean age = 45) and to explore the relations between memory impairment and depression. Objective memory impairment was evaluated using the 3(rd) edition of the Clinical Memory scale of Wechsler. Depression symptoms were evaluated using the Hamilton Depression Rating Scale. Age and education levels were controlled for all patients. Patients with mastocytosis presented high levels of cognitive impairment (memory and/or attention) (n = 22; 38.6%). Cognitive impairment was moderate in 59% of the cases, concerned immediate auditory (41%) and working memory (73%) and was not associated to depression (p≥0.717). In conclusion, immediate auditory memory and attention impairment in mastocytosis are frequent, even in young individuals, and are not consecutive to depression. In mastocytosis, cognitive complaints call for complex neuropsychological assessment. Mild-moderate cognitive impairment and depression constitute two specific but somewhat independent syndromes in mastocytosis. These results suggest differential effects of mast-cell activity in the brain, on systems involved in emotionality and in cognition. Public Library of Science 2012-06-20 /pmc/articles/PMC3379977/ /pubmed/22745762 http://dx.doi.org/10.1371/journal.pone.0039468 Text en Moura et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Moura, Daniela Silva Sultan, Serge Georgin-Lavialle, Sophie Barete, Stéphane Lortholary, Olivier Gaillard, Raphael Hermine, Olivier Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression |
title | Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression |
title_full | Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression |
title_fullStr | Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression |
title_full_unstemmed | Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression |
title_short | Evidence for Cognitive Impairment in Mastocytosis: Prevalence, Features and Correlations to Depression |
title_sort | evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379977/ https://www.ncbi.nlm.nih.gov/pubmed/22745762 http://dx.doi.org/10.1371/journal.pone.0039468 |
work_keys_str_mv | AT mouradanielasilva evidenceforcognitiveimpairmentinmastocytosisprevalencefeaturesandcorrelationstodepression AT sultanserge evidenceforcognitiveimpairmentinmastocytosisprevalencefeaturesandcorrelationstodepression AT georginlaviallesophie evidenceforcognitiveimpairmentinmastocytosisprevalencefeaturesandcorrelationstodepression AT baretestephane evidenceforcognitiveimpairmentinmastocytosisprevalencefeaturesandcorrelationstodepression AT lortholaryolivier evidenceforcognitiveimpairmentinmastocytosisprevalencefeaturesandcorrelationstodepression AT gaillardraphael evidenceforcognitiveimpairmentinmastocytosisprevalencefeaturesandcorrelationstodepression AT hermineolivier evidenceforcognitiveimpairmentinmastocytosisprevalencefeaturesandcorrelationstodepression |