DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells

Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine dimers, correctly inserting two adenines. Loss of p...

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Detalles Bibliográficos
Autores principales: Klarer, Alden C., Stallons, L. Jay, Burke, Tom J., Skaggs, Robert L., McGregor, W. Glenn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380003/
https://www.ncbi.nlm.nih.gov/pubmed/22745795
http://dx.doi.org/10.1371/journal.pone.0039596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380003/
https://www.ncbi.nlm.nih.gov/pubmed/22745795
http://dx.doi.org/10.1371/journal.pone.0039596

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