Cargando…
Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche
Adult hypothalamic neurogenesis has been recently reported, but the cell of origin and function of these newborn neurons are unknown. We utilize genetic fate mapping to show that median eminence tanycytes generate newborn neurons; blocking this neurogenesis alters weight and metabolic activity in ad...
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380241/ https://www.ncbi.nlm.nih.gov/pubmed/22446882 http://dx.doi.org/10.1038/nn.3079 |
| _version_ | 1782236301952548864 |
|---|---|
| author | Lee, Daniel A. Bedont, Joseph L. Pak, Thomas Wang, Hong Song, Juan Miranda-Angulo, Ana Takiar, Vani Charubhumi, Vanessa Balordi, Francesca Takebayashi, Hirohide Aja, Susan Ford, Eric Fishell, Gordon Blackshaw, Seth |
| author_facet | Lee, Daniel A. Bedont, Joseph L. Pak, Thomas Wang, Hong Song, Juan Miranda-Angulo, Ana Takiar, Vani Charubhumi, Vanessa Balordi, Francesca Takebayashi, Hirohide Aja, Susan Ford, Eric Fishell, Gordon Blackshaw, Seth |
| author_sort | Lee, Daniel A. |
| collection | PubMed |
| description | Adult hypothalamic neurogenesis has been recently reported, but the cell of origin and function of these newborn neurons are unknown. We utilize genetic fate mapping to show that median eminence tanycytes generate newborn neurons; blocking this neurogenesis alters weight and metabolic activity in adult mice. These findings describe a previously unreported neurogenic niche within the mammalian hypothalamus with important implications for metabolism. |
| format | Online Article Text |
| id | pubmed-3380241 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33802412012-11-01 Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche Lee, Daniel A. Bedont, Joseph L. Pak, Thomas Wang, Hong Song, Juan Miranda-Angulo, Ana Takiar, Vani Charubhumi, Vanessa Balordi, Francesca Takebayashi, Hirohide Aja, Susan Ford, Eric Fishell, Gordon Blackshaw, Seth Nat Neurosci Article Adult hypothalamic neurogenesis has been recently reported, but the cell of origin and function of these newborn neurons are unknown. We utilize genetic fate mapping to show that median eminence tanycytes generate newborn neurons; blocking this neurogenesis alters weight and metabolic activity in adult mice. These findings describe a previously unreported neurogenic niche within the mammalian hypothalamus with important implications for metabolism. 2012-03-25 /pmc/articles/PMC3380241/ /pubmed/22446882 http://dx.doi.org/10.1038/nn.3079 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Lee, Daniel A. Bedont, Joseph L. Pak, Thomas Wang, Hong Song, Juan Miranda-Angulo, Ana Takiar, Vani Charubhumi, Vanessa Balordi, Francesca Takebayashi, Hirohide Aja, Susan Ford, Eric Fishell, Gordon Blackshaw, Seth Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche |
| title | Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche |
| title_full | Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche |
| title_fullStr | Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche |
| title_full_unstemmed | Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche |
| title_short | Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche |
| title_sort | tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380241/ https://www.ncbi.nlm.nih.gov/pubmed/22446882 http://dx.doi.org/10.1038/nn.3079 |
| work_keys_str_mv | AT leedaniela tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT bedontjosephl tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT pakthomas tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT wanghong tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT songjuan tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT mirandaanguloana tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT takiarvani tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT charubhumivanessa tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT balordifrancesca tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT takebayashihirohide tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT ajasusan tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT forderic tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT fishellgordon tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche AT blackshawseth tanycytesofthehypothalamicmedianeminenceformadietresponsiveneurogenicniche |