Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell processes, that include differentiation, proliferation, apoptosis, autophagy, met...

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Detalles Bibliográficos
Autores principales: Martelli, Alberto M., Chiarini, Francesca, Evangelisti, Camilla, Cappellini, Alessandra, Buontempo, Francesca, Bressanin, Daniela, Fini, Milena, McCubrey, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380573/
https://www.ncbi.nlm.nih.gov/pubmed/22564882

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