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Structure-Function of the Tumor Suppressor BRCA1

BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11-13, and the BRCT domain. The BRCA1 RING domain is responsible for the E3 ubiquitin ligase activity o...

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Detalles Bibliográficos
Autores principales:	Clark, Serena L., Rodriguez, Ana M., Snyder, Russell R., Hankins, Gary D.V., Boehning, Darren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology (RNCSB) Organization 2012
Materias:	Mini Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380633/ https://www.ncbi.nlm.nih.gov/pubmed/22737296 http://dx.doi.org/10.5936/csbj.201204005

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