A Case of Wolfram Syndrome

PURPOSE: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. CASE REPORT: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of −0.25+1.50@55 and −0.2...

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Detalles Bibliográficos
Autores principales: Naderian, Gholamali, Ashtari, Fereshteh, Nouri-Mahdavi, Kia, Sajjadi, Valleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ophthalmic Research Center 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380670/
https://www.ncbi.nlm.nih.gov/pubmed/22737327
Descripción
Sumario:PURPOSE: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. CASE REPORT: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of −0.25+1.50@55 and −0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity. CONCLUSION: One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients.

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