A Case of Wolfram Syndrome

PURPOSE: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. CASE REPORT: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of −0.25+1.50@55 and −0.2...

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Autores principales: Naderian, Gholamali, Ashtari, Fereshteh, Nouri-Mahdavi, Kia, Sajjadi, Valleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ophthalmic Research Center 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380670/
https://www.ncbi.nlm.nih.gov/pubmed/22737327
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author Naderian, Gholamali
Ashtari, Fereshteh
Nouri-Mahdavi, Kia
Sajjadi, Valleh
author_facet Naderian, Gholamali
Ashtari, Fereshteh
Nouri-Mahdavi, Kia
Sajjadi, Valleh
author_sort Naderian, Gholamali
collection PubMed
description PURPOSE: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. CASE REPORT: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of −0.25+1.50@55 and −0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity. CONCLUSION: One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients.
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spelling pubmed-33806702012-06-26 A Case of Wolfram Syndrome Naderian, Gholamali Ashtari, Fereshteh Nouri-Mahdavi, Kia Sajjadi, Valleh J Ophthalmic Vis Res Case Report PURPOSE: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. CASE REPORT: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of −0.25+1.50@55 and −0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity. CONCLUSION: One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients. Ophthalmic Research Center 2010-01 /pmc/articles/PMC3380670/ /pubmed/22737327 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Naderian, Gholamali
Ashtari, Fereshteh
Nouri-Mahdavi, Kia
Sajjadi, Valleh
A Case of Wolfram Syndrome
title A Case of Wolfram Syndrome
title_full A Case of Wolfram Syndrome
title_fullStr A Case of Wolfram Syndrome
title_full_unstemmed A Case of Wolfram Syndrome
title_short A Case of Wolfram Syndrome
title_sort case of wolfram syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380670/
https://www.ncbi.nlm.nih.gov/pubmed/22737327
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