Cargando…
Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the major causes of blindness worldwide. The pathogenesis of DR has been investigated using several animal models of diabetes. These models have been generated by pharmacological induction, feeding a galac...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Limited
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380708/ https://www.ncbi.nlm.nih.gov/pubmed/22730475 http://dx.doi.org/10.1242/dmm.009597 |
_version_ | 1782236331292753920 |
---|---|
author | Robinson, Remya Barathi, Veluchamy A. Chaurasia, Shyam S. Wong, Tien Y. Kern, Timothy S. |
author_facet | Robinson, Remya Barathi, Veluchamy A. Chaurasia, Shyam S. Wong, Tien Y. Kern, Timothy S. |
author_sort | Robinson, Remya |
collection | PubMed |
description | Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the major causes of blindness worldwide. The pathogenesis of DR has been investigated using several animal models of diabetes. These models have been generated by pharmacological induction, feeding a galactose diet, and spontaneously by selective inbreeding or genetic modification. Among the available animal models, rodents have been studied most extensively owing to their short generation time and the inherited hyperglycemia and/or obesity that affect certain strains. In particular, mice have proven useful for studying DR and evaluating novel therapies because of their amenability to genetic manipulation. Mouse models suitable for replicating the early, non-proliferative stages of the retinopathy have been characterized, but no animal model has yet been found to demonstrate all of the vascular and neural complications that are associated with the advanced, proliferative stages of DR that occur in humans. In this review, we summarize commonly used animal models of DR, and briefly outline the in vivo imaging techniques used for characterization of DR in these models. Through highlighting the ocular pathological findings, clinical implications, advantages and disadvantages of these models, we provide essential information for planning experimental studies of DR that will lead to new strategies for its prevention and treatment. |
format | Online Article Text |
id | pubmed-3380708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Company of Biologists Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-33807082012-07-01 Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals Robinson, Remya Barathi, Veluchamy A. Chaurasia, Shyam S. Wong, Tien Y. Kern, Timothy S. Dis Model Mech Perspective Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the major causes of blindness worldwide. The pathogenesis of DR has been investigated using several animal models of diabetes. These models have been generated by pharmacological induction, feeding a galactose diet, and spontaneously by selective inbreeding or genetic modification. Among the available animal models, rodents have been studied most extensively owing to their short generation time and the inherited hyperglycemia and/or obesity that affect certain strains. In particular, mice have proven useful for studying DR and evaluating novel therapies because of their amenability to genetic manipulation. Mouse models suitable for replicating the early, non-proliferative stages of the retinopathy have been characterized, but no animal model has yet been found to demonstrate all of the vascular and neural complications that are associated with the advanced, proliferative stages of DR that occur in humans. In this review, we summarize commonly used animal models of DR, and briefly outline the in vivo imaging techniques used for characterization of DR in these models. Through highlighting the ocular pathological findings, clinical implications, advantages and disadvantages of these models, we provide essential information for planning experimental studies of DR that will lead to new strategies for its prevention and treatment. The Company of Biologists Limited 2012-07 /pmc/articles/PMC3380708/ /pubmed/22730475 http://dx.doi.org/10.1242/dmm.009597 Text en © 2012. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms |
spellingShingle | Perspective Robinson, Remya Barathi, Veluchamy A. Chaurasia, Shyam S. Wong, Tien Y. Kern, Timothy S. Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals |
title | Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals |
title_full | Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals |
title_fullStr | Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals |
title_full_unstemmed | Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals |
title_short | Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals |
title_sort | update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380708/ https://www.ncbi.nlm.nih.gov/pubmed/22730475 http://dx.doi.org/10.1242/dmm.009597 |
work_keys_str_mv | AT robinsonremya updateonanimalmodelsofdiabeticretinopathyfrommolecularapproachestomiceandhighermammals AT barathiveluchamya updateonanimalmodelsofdiabeticretinopathyfrommolecularapproachestomiceandhighermammals AT chaurasiashyams updateonanimalmodelsofdiabeticretinopathyfrommolecularapproachestomiceandhighermammals AT wongtieny updateonanimalmodelsofdiabeticretinopathyfrommolecularapproachestomiceandhighermammals AT kerntimothys updateonanimalmodelsofdiabeticretinopathyfrommolecularapproachestomiceandhighermammals |